Stockholders' Equity (Tables)
|
12 Months Ended |
Dec. 31, 2017 |
Stockholders' Equity [Abstract] |
|
Schedule of stock-based compensation |
|
|
For the Years Ended December 31, |
|
|
|
2017 |
|
|
2016 |
|
Research and development |
|
$ |
884,032 |
|
|
$ |
374,292 |
|
General and administrative |
|
|
749,453 |
|
|
|
361,137 |
|
Total |
|
$ |
1,633,485 |
|
|
$ |
735,429 |
|
|
Schedule of stock option activity |
|
|
|
|
|
|
|
|
Weighted Average |
|
|
Aggregate |
|
|
|
Stock Options |
|
|
Exercise Price |
|
|
Fair Value |
|
|
Contractual |
|
|
Intrinsic |
|
|
|
Outstanding |
|
|
Exercisable |
|
|
Outstanding |
|
|
Exercisable |
|
|
Vested |
|
|
Life (Years) |
|
|
Value |
|
Balance – December 31, 2015 |
|
|
3,724,083 |
|
|
|
1,963,948 |
|
|
$ |
0.67 |
|
|
$ |
0.34 |
|
|
$ |
0.34 |
|
|
|
7.09 |
|
|
$ |
- |
|
Granted |
|
|
1,696,000 |
|
|
|
- |
|
|
|
1.50 |
|
|
|
- |
|
|
|
- |
|
|
|
6.25 |
|
|
|
- |
|
Exercised |
|
|
(741,100 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Cancelled |
|
|
(26,486 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Balance – December 31, 2016 |
|
|
4,652,497 |
|
|
|
1,908,883 |
|
|
$ |
0.92 |
|
|
$ |
0.41 |
|
|
$ |
0.41 |
|
|
|
8.24 |
|
|
$ |
- |
|
Granted |
|
|
1,316,000 |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Exercised |
|
|
(123,333 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Cancelled |
|
|
(153,750 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Balance – December 31, 2017 |
|
|
5,691,414 |
|
|
|
3,124,941 |
|
|
$ |
1.16 |
|
|
$ |
0.73 |
|
|
$ |
0.73 |
|
|
|
6.87 |
|
|
$ |
19,142,175 |
|
|
Schedule of stock options outstanding and exercisable |
|
|
|
|
|
|
Weighted |
|
|
|
|
|
|
|
Exercise |
|
|
Number |
|
|
Average Remaining |
|
|
Weighted Average |
|
|
Number |
|
Price |
|
|
Outstanding |
|
|
Contractual Term |
|
|
Exercise Price |
|
|
Exercisable |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ |
0.05 |
|
|
|
52,876 |
|
|
|
4.25 years |
|
|
$ |
0.05 |
|
|
|
52,876 |
|
$ |
0.26 |
|
|
|
1,024,810 |
|
|
|
6.28 years |
|
|
$ |
0.26 |
|
|
|
1,022,536 |
|
$ |
0.73 |
|
|
|
1,475,687 |
|
|
|
6.87 years |
|
|
$ |
0.73 |
|
|
|
1,137,509 |
|
$ |
1.00 |
|
|
|
313,124 |
|
|
|
7.56 years |
|
|
$ |
1.00 |
|
|
|
206,457 |
|
$ |
1.10 |
|
|
|
8,000 |
|
|
|
8.02 years |
|
|
$ |
1.10 |
|
|
|
3,209 |
|
$ |
1.17 |
|
|
|
51,605 |
|
|
|
7.87 years |
|
|
$ |
1.17 |
|
|
|
22,230 |
|
$ |
1.22 |
|
|
|
70,312 |
|
|
|
8.10 years |
|
|
$ |
1.22 |
|
|
|
5,208 |
|
$ |
1.50 |
|
|
|
28,000 |
|
|
|
8.17 years |
|
|
$ |
1.50 |
|
|
|
6,333 |
|
$ |
1.55 |
|
|
|
1,456,000 |
|
|
|
8.19 years |
|
|
$ |
1.55 |
|
|
|
495,250 |
|
$ |
2.02 |
|
|
|
85,000 |
|
|
|
9.61 years |
|
|
$ |
2.02 |
|
|
|
33,750 |
|
$ |
2.40 |
|
|
|
926,000 |
|
|
|
9.08 years |
|
|
$ |
2.40 |
|
|
|
139,583 |
|
$ |
4.60 |
|
|
|
200,000 |
|
|
|
9.94 years |
|
|
$ |
4.60 |
|
|
|
- |
|
Totals |
|
|
|
5,691,414 |
|
|
|
|
|
|
|
|
|
|
|
3,124,941 |
|
|
Schedule of warrant activity |
|
|
|
|
|
|
|
|
Weighted Average |
|
|
Aggregate |
|
|
|
Warrants |
|
|
Exercise Price |
|
|
Fair Value |
|
|
Contractual |
|
|
Intrinsic |
|
|
|
Outstanding |
|
|
Exercisable |
|
|
Outstanding |
|
|
Exercisable |
|
|
Vested |
|
|
Life (Years) |
|
|
Value |
|
Balance – December 31, 2015 |
|
|
7,936,391 |
|
|
|
7,936,391 |
|
|
$ |
1.80 |
|
|
$ |
1.80 |
|
|
$ |
0.41 |
|
|
|
1.80 |
|
|
$ |
- |
|
Granted |
|
|
490,550 |
|
|
|
428,050 |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Exercised |
|
|
(1,745,890 |
) |
|
|
(1,745,890 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Cancelled |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Balance – December 31, 2016 |
|
|
6,681,051 |
|
|
|
6,618,551 |
|
|
$ |
1.74 |
|
|
$ |
1.74 |
|
|
$ |
0.41 |
|
|
|
0.98 |
|
|
$ |
- |
|
Granted |
|
|
3,618,053 |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Exercised |
|
|
(1,070,238 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Cancelled |
|
|
(4,695,846 |
) |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
Balance – December 31, 2017 |
|
|
4,533,020 |
|
|
|
4,517,395 |
|
|
$ |
1.85 |
|
|
$ |
1.85 |
|
|
$ |
1.00 |
|
|
|
3.21 |
|
|
$ |
14,280,372 |
|
|